Los Blancos will welcome Atletico to the Bernabeu boasting a two-point lead over Barcelona at the top of the table and with a game in hand over their fierce rivals as they look for their first league title since 2012.
Real captain Sergio Ramos has been Atletico's bete noire in recent times, scoring in both the Champions League finals between the sides.
Cristiano Ronaldo holds the record for goals in the Madrid derby with 18 following his hat trick in November to earn a 3-0 victory for Real Madrid at the Vicente Calderon Stadium.
Fellow center back Raphael Varane missed Saturday's match with a muscle injury.
According to his agent, an array of top football clubs including City, United, Chelsea, Barcelona and Real Madrid are keen to lure the talented attacker away from Madrid.
Ronaldo was rested, along with Gareth Bale and Karim Benzema, for the match against Leganes on Wednesday, preparing them for a huge effort in the derby.
"Madrid played great and caused us a lot of damage". That's why the Real Madrid defense will be so pivotal.
Trump, declining to provide evidence, says thinks Obama adviser Rice committed crime
This is a real problem. "I don't expect they will (declassify) because I think this is just more obstruction", Swalwell said. Are we threatened now by Syria, and if we go to war is Assad likely to use less chemical weapons or more?
Most of Atletico Madrid's hopes to beat crosstown rival Real Madrid will ride on the shoulders of Antoine Griezmann. He dedicated his 23rd goal in all competitions to his daughter who turned one on Saturday.
Following a minute's silence before kick-off to commemorate Antonio Lamela, the architect who designed Real Madrid's Valdebebas training complex, and also to honour the victims of Friday's attack in Stockholm, the match got off to a less-than-energetic start.
Real Madrid can not afford to drop any point with Barcelona hot on their heels, even though they have a buffer of two points and one game on their bitter rivals.
Joaquin Correa was introduced into the frame as Atletico searched for an equaliser but the home side's defence was standing firm.
Atletico did not trouble the hosts too much until Griezmann levelled with his 15th league goal of the season.
"The truth is that, for us, it's the same as going to any other ground because we always need the points and [this weekend] is no different".